Causal Attributions, Implicit Beliefs, and Immutability from the Perceptions of Pedophiles

Pedophilic immutability is a complex phenomenon that has been challenging to understand. Perceptions of pedophiles have largely been ignored in understanding how pedophilic immutability develops. However, relationships between causal attributions and implicit beliefs may provide evidence for new conceptualizations related to pedophilic immutability. The purpose of this study was to explore pedophiles’ perceptions directly with attribution and implicit theory as key foundational principles of pedophilic immutability. Research questions were developed to allow for rich description from participants regarding their causal attributions and implicit beliefs associated with pedophilic immutability. Qualitative exploration was necessary to address the dearth of research related to pedophilic immutability focusing on pedophiles’ perceptions. Four male individuals volunteered and participated in the research study interviews. Thematic analysis was used to identify common themes among causal attribution and implicit beliefs that are associated with pedophilic immutability. Major themes identified during thematic analysis included that pedophilia development is complex, nature then nurture, nothing I can do about it, never believed but tried and failed, reality for pedophiles, and change is ambiguous. External causal attributions led to entity implicit beliefs related to pedophilic immutability, which was likely a main factor behind that particular mindset. A more diverse population with a deeper sample size would provide stronger evidence for some of the resulting interpretations. The findings from this study can be used to facilitate positive social change through development of a conceptual framework and a more comprehensive societal view of pedophilic immutability

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

[Excerpt] Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS) [1], and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM [2]. The somatic mutational landscape of sporadic MM has been increasingly investigated, aiming to identify recurrent genetic events involved in myelomagenesis. Whole exome and whole genome sequencing studies have shown that MM is a genetically heterogeneous disease that evolves through accumulation of both clonal and subclonal driver mutations [3] and identified recurrently somatically mutated genes, including KRAS, NRAS, FAM46C, TP53, DIS3, BRAF, TRAF3, CYLD, RB1 and PRDM1 [3,4,5]. Despite the fact that family-based studies have provided data consistent with an inherited genetic susceptibility to MM compatible with Mendelian transmission [6], the molecular basis of inherited MM predisposition is only partly understood. Genome-Wide Association (GWAS) studies have identified and validated 23 loci significantly associated with an increased risk of developing MM that explain ~16% of heritability [7] and only a subset of familial cases are thought to have a polygenic background [8]. Recent studies have identified rare germline variants predisposing to MM in KDM1A [9], ARID1A and USP45 [10], and the implementation of next-generation sequencing technology will allow the characterization of more such rare variants. [...]French National Cancer Institute (INCA) and the Fondation Française pour la Recherche contre le Myélome et les Gammapathies (FFMRG), the Intergroupe Francophone du Myélome (IFM), NCI R01 NCI CA167824 and a generous donation from Matthew Bell. This work was supported in part through the computational resources and staff expertise provided by Scientific Computing at the Icahn School of Medicine at Mount Sinai. Research reported in this paper was supported by the Office of Research Infrastructure of the National Institutes of Health under award number S10OD018522. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors thank the Association des Malades du Myélome Multiple (AF3M) for their continued support and participation. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organizatio

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

Flume experiments on turbulent flows across gaps of permeable and impermeable boundaries

Laser Doppler anemometery and laser-induced fluorescence techniques were used to explore the spatial structure of the flow within and above finite cavities created within porous and solid media. The cavities within these two configurations were identical in size and were intended to mimic flow disturbances created by finite gaps and forest clearing. Because flows over permeable boundaries differ from their solid counterparts, the study here addresses how these differences in boundary conditions produce differences in, (i) bulk flow properties including the mean vorticity within and adjacent to the gaps, (ii) second-order statistics such as the standard deviations and turbulent stresses, (iii) the relative importance of advective to turbulent stress terms across various regions within and above the gaps, and (iv) the local imbalance between ejections and sweeps and momentum transport efficiencies of updrafts and downdrafts. Both configurations exhibited a primary recirculation zone of comparable dimensions inside the gap. The mean vorticity spawned at the upstream corner of the gap was more intense for the solid configuration when compared to its porous counterpart. The free-shear layer spawned from the upstream corner-edge deeper into the gap for the porous configuration. The momentum flux at the interface within and above the gap was enhanced by a factor of 1.5–2.0 over its upstream value, and this enhancement zone was much broader in size for the porous configuration. For the turbulent transport terms in the longitudinal and vertical mean momentum balances, these transport terms were significant inside the gap for both boundary configurations when compared to their upstream counterpart. The effectiveness of using incomplete cumulant expansion methods to describe the momentum transport efficiencies, and the relative contributions of ejections and sweeps to turbulent stresses, especially in this zone, were also demonstrated. The flatness factor for both velocity components, often used as a measure of intermittency, was highest in the vicinity of the upstream corner in both configurations. However, immediately following the downstream corner, the flatness factor remained large for the porous configuration, in contrast to its solid configuration counterpart

Chapitre 11. Géologie et minéralogie

© IRD/c. Giuliani – Les saphirs et les rubis de Madagascar : coupe d'un des placers d'Ilakaka. Ce chapitre est dédié à la mémoire de François Fontan. Introduction Le présent chapitre a pour but de retracer la contribution des géologues et minéralogistes français et malgaches à l’histoire de la connaissance géologique et minière de Madagascar. Terre de prédilection pour la minéralogie, la Grande Île a fasciné les chercheurs par la richesse et l’originalité de ses espèces minérales. Elle a acc..

CHESSSS: A Free Software Solution to Score and Compute the Rorschach Comprehensive System and Supplementary Scales.

International audience[No abstract

PHYSICALCHEMICAL CHARACTERIZATION AND THERMOPHYSICAL PROPERTIES OF COCOA HONEY

The objective of this study was to determine the physicochemical characteristics and thermophysical properties of cocoa hoeny. The cocoa honey had the following physicalchemical characteristics: pH (2.76), titratable acidity (0.73 %), moisture (87,22 %), soluble solids (14,03 °Brix), reducing sugar (10,2 % in glucose), non-reducing sugar (4,06 % in saccharose) and ash (0,23 %). With respect to the thermophysical properties were determined the specific heat, density, thermal diffusivity and the dynamic viscosity as a function of temperature. The empirical models for each property were obtained. It was found that the temperature directly affects the cocoa liquor properties. The data are important for the development, adaptation and optimization of equipment for more efficient processing of cocoa honey, since the information on this subject is unknown.</p

Serum free light chains should be the target of response evaluation in light chain multiple myeloma rather than urines.

Guidelines for monitoring multiple myeloma patients expressing light chains only (light chain multiple myeloma; LCMM) rely on measurements of the monoclonal protein in urine. Alternatively serum free light chain (sFLC) measurements have better sensitivity over urine methods, however, demonstration that improved sensitivity provides any clinical benefit is lacking. Here we compared the performance of serum and urine measurements in 113 (72κ, 41λ) newly diagnosed LCMM patients enrolled onto the IFM-2009 trial. All diagnostic samples (100%) had an abnormal κ/λ sFLC ratio, and involved (monoclonal) FLC (iFLC) expressed at levels deemed measurable for monitoring (≥100mg/L). By contrast, only 64% patients had measurable levels of the monoclonal protein (≥200mg/24h) in urine protein electrophoresis (UPEP). After 1 and 3 treatment cycles, iFLC remained elevated in 71% and 46% patients, respectively, whilst UPEP reported a positive result in 37% and 18%; all the patients with a positive UPEP at cycle 3 also had elevated iFLC levels. Importantly, elevated iFLC or an abnormal κ/λ sFLC ratio after 3 treatment cycles associated with poorer PFS (p=0.006 and p<0.0001, respectively), whereas positive UPEP or urine immunofixation (uIFE) did not. In addition, patients with an abnormal κ/λ sFLC ratio had poorer overall survival (p=0.022). Finally, early normalisation of κ/λ sFLC ratio but not negative uIFE predicted achieving negative minimal residual disease, as determined by flow cytometry, after consolidation therapy (100% positive predictive value). We conclude that improved sensitivity and prognostic value of serum over urine measurements provide a strong basis for recommending the former for monitoring LCMM patients